The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.?
Properties
IHC Recommended dulition
25-100
IHC positive control
Human liver and esophagus cancer
IHC predicted cell location
Cytoplasm and Cell membrane
ELISA Recommended dilution
2000-5000
SwissProt
O75027
Synonyms
ABC7; ASAT; Atm1p; EST140535
Full name
ATP-binding cassette, sub-family B (MDR/TAP), member 7
Content(mg/ml)
0.9
Immunogen
Fusion protein of human ATP-binding cassette, sub-family B (MDR/TAP), member 7
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