The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
Properties
IHC Recommended dulition
30-150
IHC positive control
Human liver cancer
IHC predicted cell location
Cytoplasm
ELISA Recommended dilution
2000-10000
SwissProt
Q92887
Synonyms
DJS; MRP2; cMRP; ABC30; CMOAT
Full name
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Content(mg/ml)
2.9
Immunogen
Synthetic peptide of human ATP-binding cassette, sub-family C (CFTR/MRP), member 2
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